Title:
Catalysis at Nanoscale: One Step Towards Green and Sustainable Processes

Speaker:
Diwan S. Rawat
Department of Chemistry, University of Delhi, Delhi-110007, INDIA
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Abstract:
Organic reactions can be promoted by homogeneous or heterogeneous catalysis, but later offers many advantages such as recyclability, easy workup and less waste production.1 The global concern about the climate change, energy production and conservation has prompted scientists to develop efficient recyclable heterogeneous catalysts for industrial processes. The study of  heterogeneous catalysis started with the industrial revolution in the early 1800s.2 Several solid base catalysts such as zeolites, metal oxides, mixed oxides, hydrotalcites etc. have been developed for the manufacture of organic intermediates and fine chemicals, among them metal oxides such as MgO and ZnO are of especial interest. During the synthesis of medicinally relevant molecules,3 we became interested to develop heterogeneous catalytic system that can be used for more than one organic transformation.4 Hydromagnesite, a precursor of MgO, ferrite and reduced graphene oxide (RGO)/ZnO composite5 have not been well studied as catalyst for organic transformations, so we became interested to explore the catalytic potential of these materials. Thus, the synthesized materials were explored as novel recyclable heterogeneous catalysts for the synthesis of variety of organic molecules.6  Some of the organic molecules synthesized during this work have been evaluated for antimalarial activity and have exhibited potent in vitro and in vivo antimalarial activity.

References

  1. Thomas, J. M. Angew. Chem. Int. Ed. 1999, 38, 3588.
  2. C. Baleizão, H. Garcia, Chem. Rev. 2006, 106, 3987.
  3. (a) H. Atheaya, D. S. Rawat, et al, Bioorg. Med. Chem. Lett. 2008, 18, 1446.  (b) N. Kumar, D. S. Rawat, et al, Bioorg. Med. Chem. Lett. 2009, 19, 1675. (c) N. Kumar, D. S. Rawat, et al, Med. Res. Rev. 2012, 32, 581. (d) S. Manohar, D. S. Rawat, et al, Bioorg. Med. Chem. Lett. 2010, 20, 322. (e) N. Kumar, D. S. Rawat, et al, Eur. J. Med. Chem. 2011,  46, 2816. (f) N. Kumar, D. S. Rawat, et al, Curr. Med. Chem. 2011, 18, 3889. (g) S. Manohar, D. S. Rawat, et al, Chem. Biol. Drug Des. 2011, 78, 124. (h) S. Manohar, D. S. Rawat, et al, ACS Med. Chem. Lett. 2012, 3, 555. (i) N. Kumar, D. S. Rawat, et al, Helv. Chim. Acta 2012, 95, 1181. (j) D. Kumar, S.I. Khan, P. Poonan, D. S. Rawat,  New J. Chem. 2014, 38, 5087. (k) A. Thakur, S. I. Khan, D.S. Rawat, RSC Adv. 2014, 4, 20729.
  4. (a) K. Arya, U. C. Rajesh, D. S. Rawat, Green Chem. 2012, 14, 3344. (b) K. Arya, D. S. Rawat, A. Dandia, H. Sasai, Green Chem. 2012, 14, 1956.
  5. J. Wang, T. Tsuzuki, B. Tang, X. Hou, L. Sun and X. Wang, ACS Appl. Mater. Interfaces, 2012, 4, 3084.
  6. (a) U. C. Rajesh, S. Manohar, D. S. Rawat, Adv. Synth. Catal. 2013, 355, 3170. (b) A. Thakur, M. Tripathi, U. C. Rajesh,  D. S. Rawat, RSC Adv. 2013, 3, 18142. (c) U. C. Rajesh, Divya, D. S. Rawat, RSC Adv 2014, 4, 41323. (d) U. C. Rajesh, R. Kholiya, V. S. Pavan, D. S. Rawat, Tetrahedron Letters 2014, 55, 2977. (e) U. Chinna Rajesh, V. Satya Pavan, D. S. Rawat, ACS Sustainable Chem. Eng. Accepted (2015). (f) U. Chinna Rajesh, Rohit Kholiya, Anuj Thakur, D. S. Rawat, Tetrahedron Lett. 2015, 56, 1790. (g) U. Chinna Rajesh, Jinfeng Wang, Stuart Prescott,  Takuya Tsuzuki, D. S. Rawat, ACS Sustainable Chem. Eng. 2015, 3, 9.