Major Research Areas：Bioamterials, Bioorganic Chemistry
Doctor：Yoshiko Miura
MIURA Laboratory
Glyco-biomaterials
　Research activity
　
Biomaterial fabrication with bioactive saccharides
Sasccharides on the cell surfaces play important roles in the living processes to mediate the biological signals via proteinsaccharides interaction. We investigate the biomaterials with the bioactive saccharides by mimicking the cell surfaces. These biomaterials can be applicable for medicinal chemistry and biotechnology.

1）Biosensing devices with saccharides.
Saccharides on the cell surfaces relate to various diseases such as influenza, food poisoning and senile dementia. We have developed biosensing devices of Shiga toxins from E. coli O157 and Alzheimer diseases with the saccharide-immobilized substrate. We are investigating highly sensitive biosensors with saccharides.

2）Biomaterials with saccharides.
The glycopolymers with pendant saccharide have strong bioactivity and applicability for biomaterials. We are investigating the polymer medicines for Alzheimer diseases.

3）Green chemistry for saccharide materials
The saccharides are useful biomolecules, but the synthesis and modification are usually tedious due to the multi-step reactions of protective groups and the low-yield glycosylation processes. On the other hand, enzymes are advantageous for the modification of carbohydrates due to their high catalytic activities and chemoselective reactions. We are investigating the synthesis of glyco-materials using chemoenzymatic processes.
■Equipment
NMR, High performance liquid chromatography (HPLC), Ultra visible spectroscopy, Infrared absorption spectroscopy, Cyclic voltammetry (CV), Surface plasmon resonance (SPR), Dynamic light scattering (DLS), AFM
　
Voice If you have an interest in biomaterials and bioorganic chemistry, please join us. We investigate novel biomaterials with saccharides. Saccharides are not only sweet.
　
■Keywords
■Contact
 Biomaterials, Saccharide, Biosensing
Yoshiko Miura／E-mail：miuray@jaist.ac.jp　TEL：+81-761-51-1641 　FAX：+81-761-51-1641
URL：http://www.jaist.ac.jp/ms/labs/miura/
　
The main research achievements in the past five years
1: H. Sato, Y. Miura, N. Saito, K. Kobayashi, O. Takai, A Micropatterned Multifunctional Carbohydrate Display by an Orthogonal Self-Assembling Strategy,Biomacromolecules, in press(2007).
2: Y. Miura, A. Sakaki, M. Kamihira, S. Iijima, K. Kobayashi, A globotriaosylceramide (Gb3Cer) mimic peptide isolated from phage display library expressed strong neutralization to Shiga toxins, Biochim Biophys Acta, 1760, 883(2006).
3: Y. Yamada, Y. Miura, A. Sakaki, T. Yoshida, K. Kobayashi, Design of multifunctional peptides expressing both antimicrobial activity and shiga toxin neutralizing activity,Bioorg. Med. Chem. 14, 77 (2006).
4: V. Percec, A. E. Dulecy, V. S. K. Bulagurusamy, Y. Miura, J. Samidrkal, M. Peterca, S. Nummelin, U. Edlund, S. D. Hudson, P. A. Heiney, H. Duan, S. N. Magonov, S.A. Vinogradov., Self-Assembly of amphiphilic dendritic dipeptides into helical pores, Nature, 430, 764(2004).
5: Y. Miura, H. Sato, T. Ikada, H. Sugimura, O. Takai, K. Kobayashi, Micro-patternd Carbohydrate Displays by Self-Assembly of Glycoconjugate Polymers on Hydrophobic Templates on Silicon, Biomacromolecules, 5, 1708(2004).