中村重孝

 

学歴



2006. 3  京都私立洛南高等学校 卒業
2006. 4  早稲田大学理工学部電気情報生命工学科 入学
2010. 3  早稲田大学理工学部電気情報生命工学科 卒業
2012. 3  北陸先端科学技術大学院大学マテリアルサイエンス研究科    
         マテリアルサイエンス専攻博士前期過程 修了
2015. 3  北陸先端科学技術大学院大学マテリアルサイエンス研究科
         マテリアルサイエンス専攻博士後期課程 修了
         博士(マテリアルサイエンス)

受賞

 

2016: 優秀発表者賞(川原賞) 核酸医薬学会

 

研究業績

 

査読付国際論文誌
1)     “Wash-free RNA FISH using a photoresponsive beacon probe via photochemical cross-linking"
    Shigetaka Nakamura, Chinami Kano, Kenzo Fujimoto
    Chem. Lett., 2017, accepted.
2)     “Photochemical acceleration of DNA strand displacement using ultrafast DNA photo-cross-linking”
    Shigetaka Nakamura, Hirokazu Hashimoto, Satoshi Kobayashi, Kenzo Fujimoto
    ChemBioChem, 2017, in press,
3)     “Double duplex invasion of DNA induced by ultrafast photo-cross-linking using 3-cyanovinylcarbazole toward for antigene method”
    Shigetaka Nakamura, Hayato Kawabata, Kenzo Fujimoto
    
Chemical Communications, 2017, 53, 7616 - 7619.
4)     “Effect of substitution of photo-cross-linker in photochemical cytosine to uracil transition in DNA”
    Siddhant Sethi, Yasuharu Takashima, Shigetaka Nakamura, Kenzo Fujimoto
    
Bioorg. Med. Chem. Lett., 2017, 27, 16, 3905 - 3908.
5)     “Development of 19F-NMR chemical shift detection of DNA B-Z equilibrium using 19F-NMR"
    Shigetaka Nakamura, Yang Hui, Chihiro Hirata, Florian Kersaudy, Kenzo Fujimoto,
    Organic & Biomolecular Chemistry , 2017, 15, 5109 - 5111.

6)     “Sequence-specific DNA photo-splitting of 3-cyanovinylcarbazole using DNA strand displacement
    Shigetaka Nakamura, Hayato Kawabata, Kenzo Fujimoto.
    ChemBioChem.,  2016, 17, 1499-1503.
7)     “The effect of 5-substitution of uracil base in DNA photo-cross-linking using 3-cyanovinylcarbazole”
    Shigetaka Nakamura, Hayato Kawabata, Hodaka Muramatsu, Kenzo Fujimoto.
     Chem. Lett., 2016, 45, 887-889.
8)     “UVA Responsive Anticancer Prodrug Based on Photoinduced Electron Injection into Oligonucleotide Having 5-Halouracils”
    Kenzo Fujimoto, Mirei Furusawa, Shigetaka Nakamura, Takashi Sakamoto
     Chem. Lett.
, 2016, 45, 1078-1080.
9)     “RNA fluoreacence in situ hybridization using 3-cyanovinylcarbazole modified oligodeoxyribonucleotide as photo-cross-linkable probes”
    Kenzo Fujimoto, Kei Toyosato, Shigetaka Nakamura, Takashi Sakamoto
     
Bioorg. Med. Chem. Lett.,, 2016, 26, 5312 - 5314.
10)     “Photo-cross-linking using trifluorothymidine and 3-cyanovinylcarbazole induced large shifted 19F MR signal”
    Shigetaka Nakamura, Kenzo Fujimoto,
     ChemCommun., 2015, 51, 11765-11768.
11)     “Creation of DNA Array Structure Equipped with heat resistance by Ultrafast Photcrosslinking”
     Shigetaka Nakamura, Kenzo Fujimoto.
     J. Chem. Technol. Biotechnol., 2014, 89, 1086-1090.
12)     “Tempalte Directed Reversible Photochemical Ligation of Oligodeoxynucleotide”
     Shigetaka Nakamura, Kenzo Fujimoto.
     Molecules, 2012, 17, 163-178.     

 
査読付国際会議
1)        “The reversible photochemical reaction using branch migration”
      Shigetaka Nakamura, Hayato Kawabata, Kenzo Fujimoto.
      The 41st International Symposiumu on Nucleic Acids Chemistry. November, 2014, in Kokura
2)        “Photochemical regulation of DNA strand exchange using DNA photocrosslinking” 
      Shigetaka Nakamura, Hirokazu Hashimoto, Kenzo Fujimoto.
      20thInternational Conference on DNA computing and Molecular Programming, September, 2014, in Kyoto.
3)        “Improvement of thermal stability of DNA structure by photocrosslinking reaction using 3-cynaovinylcarbazole” 
      Shigetaka Nakamura, Kenzo Fujimoto.
      ISACS15 Challenge in Nanoscience, August, 2014, in San Diego.
4)        “Creation of DNA array structure equipped with heat resistance by ultrafast photocrosslinking using 3-cyanovinylcarbazole” 
      Shigetaka Nakamura, Kenzo Fujimoto.
      The XXVth IUPAC Symposium on Photochemistry, July, 2014, in Bordeaux.
5)        “Template directed photochemical organization of oligonucleotides” 
      Shigetaka Nakamura, Kenzo Fujimoto.
      The 39th International Symposium on Nucleic Acids Chemistry, November, 2012, in Nagoya.
6)        ”Template directed reversible photochemical ligation toward for construction of DNA architecture” 
      Shigetaka Nakamura, Kenzo Fujimoto.
      13th Tetrahedron Symposium, June, 2012, in Amsterdam.
7)        “Template directed reversible photochemical ligation for DNA nanotechnology” 
      Shigetaka Nakamura, Kenzo Fujimoto.
      ACS national Meeting 2012 spring, March, 2012, in San Diego.
8)        “Photochemical DNA manipulation toward for DNA computing” 
      Shigetaka Nakamura, Shinzi Ogasawara, Kenzo Fujimoto.
      17th International Conference on DNA computing and Molecular Programming, September, 2011, in Los Angeles.
9)        ”Catalytic Repair of a Thymine Dimer in DNA via Carbazole Nucleoside and its Application for DNA Nanotechnology” 
      Shigetaka Nakamura, Yoshinaga Yoshimura, and Kenzo Fujimoto.
       XXV International Conference on Photochemistry, August, 2011, in Beijing.
10)      “DNA computing based on photochemical DNA manipulation.” 
      Shigetaka Nakamura, Takehiro Ami, Shinzi Ogasawara, Takashi Sakamoto, and Kenzo Fujimoto.
      The 2010 International Chemical Congress of Pacific basin Societies. December, 2010, in Hawaii.
特許
1)     アンチジーン法用光応答性人工核酸プローブ
    発明者:藤本 健造、中村重孝        特願2016-105622
2)     光架橋核酸二重鎖の光架橋を光開裂させる方法
    発明者:藤本 健造、中村重孝        特願2014-224574
3)     光架橋形成によって19Fケミカルシフトの変化を生じさせる方法
    発明者:藤本 健造、中村重孝        特願2013-259334
4)     光架橋形成抑制方法、及び自己架橋形成抑制型光応答性核酸
    発明者:藤本 健造、中村重孝        特願:2013-225799
5)     鎖交換された二重鎖オリゴヌクレオチドの製造方法
    発明者:藤本 健造、中村重孝、橋本 浩寿、小林 聡  特願:2013-133163
6)     核酸ナノワイヤーの製造方法、該方法に使用される核酸、および該方法によって製造される核酸ナノワイヤー
    発明者:藤本 健造、中村重孝        特願:2012-159889