OHKI, Shinya Professor, Director of Center for Nano Materials and Technology
Materials Science, Bioscience, Biotechnology, and Biomedical Engineering, Center for Nano Materials and Technology
◆Degrees
Ph.D. (1996) received from Hokkaido University 北海道大学
◆Research Interests
Structural Biology
(1) Structure-activity relationship of phosphorylation-dependent protein inhibitors. (2) Structure-activity relationship of metal-binding proteins.
Application of Protein NMR
(1) Structure determination.(2) Interaction of proteins with targets (peptides, ions, etc.).(3) Physical & chemical properties of proteins.

■Publications

◆Published Papers
Zinc finger domains bind low-complexity domain polymers
Naohiko Iguchi, Noriyoshi Isozumi, Yoshikazu Hattori, Tomohiro Imamura, Masatomo So, Hitoki Nanaura, Takao Kiriyama, Nobuyuki Eura, Minako Yamaoka, Mari Nakanishi, Masashi Mori, Shinya Ohki, Hiroyuki Kumeta, Hironori Koga, Mai Watabe, Takuya Mabuchi, Shingo Kanemura, Masaki Okumura, Takuya Yoshizawa, Ichiro Ota, Naoki Suzuki, Masashi Aoki, Yoshito Yamashiro, Tomohide Saio, Kazuma Sugie, Eiichiro Mori
-, 2023
Mutation-driven evolution of antibacterial function in an ancestral antifungal scaffold: Significance for peptide engineering
Jing Gu, Noriyoshi Isozumi, Bin Gao, Shinya Ohki, Shunyi Zhu
Frontiers in Microbiology, 13, -, 2022
Structural and functional studies of LaIT2, an antimicrobial and insecticidal peptide from Liocheles australasiae
Maiki Tamura, Chiharu Tatsushiro, Eugene Hayato Morita, Shinya Ohki
Toxicon, 214, 8-17, 2022
Red-Beet Betalain Pigments Inhibit Amyloid-β Aggregation and Toxicity in Amyloid-β Expressing Caenorhabditis elegans
Tomohiro Imamura, Noriyoshi Isozumi, Yasuki Higashimura, Hironori Koga, Tenta Segawa, Natsumi Desaka, Hiroki Takagi, Kenji Matsumoto, Shinya Ohki, Masashi Mori
Plant Foods for Human Nutrition, 77, 1, 90-97, 2022
Adaptively evolved human oral actinomyces‐sourced defensins show therapeutic potential
Shunyi Zhu, Bin Gao, Yoshitaka Umetsu, Steve Peigneur, Ping Li, Shinya Ohki, Jan Tytgat
EMBO Molecular Medicine, -, 2021
◆Misc
植物の気孔密度を調節する機構
大木進野, 森正之
NMR (Web), 5, 32‐38 (WEB ONLY)-38, 2014
calmodulinのprotein4.1R由来ペプチド(pep11)の結合部位
布村渉, 五十棲規嘉, 大木進野, 高桑雄一
東京女子医科大学総合研究所紀要, 32, 24-25, 2012
ダイニン微小管結合部位の構造と機能
加藤 有介, 八木 俊樹, 大木 進野, 由良 敬, 清水 洋輔, 本田 真也, 神谷 律, 田之倉 優
バイオイメージング, 17, 2, 204-205, 2008
◆Books
基礎から学ぶ構造生物学 第5章「基本的な2次構造を持つタンパク質」
69-80, 共立出版, 2008
Advances in Experimental Medicine and Biology vol.592 (Regulatory Mechanisms of Striated Muscle Contraction) Structural Basis for Calcium Regulated Relaxation of Striated Muscle at Interaction Sites of Troponin with Actin and Tropomyosin
71-86, Springer (Eds. S.Ebashi & I.Ohtsuki), 2007
Recent Developments in Stable-Isotope-Aided Mathods for Protein NMR Spectroscopy in Modern Magnetic Resonance (Ed. G.A.Webb)
共著, pp. 211-218, Springer, 2006
「ライフサイエンス系の機器分析」第5章NMR
共著, 80-85, 三共出版, 2004
◆Conference Activities & Talks
Structure and dynamics of LaIT2, a toxic peptide, from Japanese scorpion, Liocheles australasiae
60th Annual Meeting of the Nuclear Magnetic Resonance Society of Japan (NMRSJ 2021), 2021
CoDN3, an Effector of Colletotrichum Orbiculare, Is an IDP (Intrinsically Disordered Protein) That Binds to Calmodulin in a Ca2+ Dependent Manner
第20回日本蛋白質科学会年会, 2020
Structural Modeling Of LaIT2 As A Peptide Toxin In The Venom Of Japanese Scorpion Liocheles australasiae, With Cross Validation Experiments Using Polyclonal Antibodies For LaIT2 And C-LaIT2
第20回日本蛋白質科学会年会, 2020
Solution NMR structure of LaIT2, an antimicrobial peptide of Yaeyama scorpion (Liocheles australasiae)
第20回日本蛋白質科学会年会, 2020
ヤエヤマサソリ由来殺虫性毒素LaIT2のC末端ドメインの大腸菌大量発現系構築と精製方法の確立
日本生化学会北陸支部第38回大会, 2020

■Teaching Experience

Analysis of Nano-Materials with Training Course, Advanced Biomolecular Science (E), Biofunction and Organization(E), ナノ分子解析論(実習付), 先端生体分子科学特論(E), バイオ機能・組織化特論(E)

■Contributions to  Society

◆Academic Society Affiliations
日本プロテインホスファターゼ研究会, 日本核磁気共鳴学会, 日本タンパク質科学会, The biophysical society of Japan
◆Academic Contribution
27th ICMRBS (International Conference on Magnetic Resonance in Biological Systems) , 2016 - 2016 , organizing committee member
JAIST NT2006 , 実行委員 , 2006 - 2006
JAIST NT2004 , 実行委員 , 2004