Shin-ya Ohki Professor
Center for Nano Materials and Technology

■Degrees

B.S. (1989), M.S. (1991), and Ph.D. (1996) received from Hokkaido University

■Professional Career

Technician at Hokkaido University (1993), Assistant Professor at Hokkaido University (1995), Research Associate at Hong Kong University of Science and Technology (HKUST) (1996), CREST/JST Research Scientist (1997), Associate Professor at JAIST (2002)

■Specialties

protein NMR, structural biology, biophysics

■Research Keywords

structure-function relationship of proteins related to signal transduction

■Research Interests

Structural Biology
(1) Structure-activity relationship of phosphorylation-dependent protein inhibitors. (2) Structure-activity relationship of metal-binding proteins.
Application of Protein NMR
(1) Structure determination.(2) Interaction of proteins with targets (peptides, ions, etc.).(3) Physical & chemical properties of proteins.

■Publications

◇Books

Advances in Experimental Medicine and Biology vol.592 (Regulatory Mechanisms of Striated Muscle Contraction) "Structural Basis for Calcium Regulated Relaxation of Striated Muscle at Interaction Sites of Troponin with Actin and Tropomyosin"，K.Murakami, F.Yumoto, S.Ohki, T,Yasunaga, M.Tanokura & T.Wakabayashi，Springer (Eds. S.Ebashi & I.Ohtsuki)，2007，71-86
"Recent Developments in Stable-Isotope-Aided Mathods for Protein NMR Spectroscopy" in Modern Magnetic Resonance (Ed. G.A.Webb)，S.Ohki & M.Kainosho，Springer，2006，pp. 211-218

◇Published Papers

Novel Mechanism of Regulation of Protein 4.1G Binding Properties Through Ca2+/Calmodulin-Madiated Structural Changes，W.Nunomura, Y.Jinbo, N.Isozumi, S.Ohki, Y.Izumi, N.Matsushima & Y.Takakuwa.，Cell Biochem. Biophys.，DOI:10.1007/s12013-012-9502-7.
Structural Characterization of a Trapped Folding Intermediate of Pyrrolidone Carboxyl Peptidase from a Hyperthermophile，M. Mizuguchi, M. Takeuchi, S. Ohki, Y. Nabeshima, T. Kouno, T. Aizawa, M. Demura, K. Kawano & K. Yutani，Biochemistry，51，6089-6096，2012
Alternative splicing produces structural and functional changes in CUGBP2，H. Suzuki, M. Takeuchi, A. Sugiyama, A. K. Alam, L. T. Vu, Y. Sekiyama, H. C. Dam, S. Ohki & T. Tsukahara，BMC Biochemistry，13，6，2012

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◇Lectures and Presentations

Uniform and Site-specific 13C-labeling in Proteins Using Plant BY-2 Cells with Inducible Virus Vectors，M. Takeuchi, M. Mori & S. Ohki，ISNMR2011 (International Symposium on Nuclear Magnetic Resonance 2011. 第50回NMR討論会記念国際シンポジウム），横浜，2011/11/15-18
Protein sample preparation with plant cells; expression and labeling，S.Ohki, M.Takeuchi, A.Tamai, and M.Mori，24th ICMRBS，Cairns, Australia，2010年8月22～27日
難易度の高いタンパク質試料の調製方法と標識技術の開発，大木進野，Bio Japan 2009，横浜，2009年10月7～9日