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Takahiro Hohsaka Professor
School of Materials Science、Bioscience and Biotechnology Area


B.E.(1992), M.E.(1994), and Ph.D.(2002) from Tokyo Institute of Technology

■Professional Career

Research Associate, Okayama University (1994-2003), PRESTO Researcher, Japan Science and Technology Agency(2002-2006)


Extended genetic engineering, Biomolecular engineering, Chemical biology

■Research Keywords

Nonnatural amino acid, Cell-free translation, Artificial protein, Four-base codon, Fluorescence

■Research Interests

Incorporation of Nonnatural Amino Acids into Proteins through Extension of the Genetic Code
We have developed a novel system that allows us to introduce "nonnatural amino acids" into specific positions of proteins by using "four-base codons". Using this system, the following studies are in progress.
- Structural and functional analysis of proteins by introducing fluorescent amino acids
- Improvement of technology for nonnatural amino acid incorporation
- Incorporation of modified amino acids into proteins
- Development of novel site-directed mutagenesis technology


◇Published Papers

  • Freezing Assisted Gene Delivery Combined with Polyampholyte Nanocarriers.,Ahmed S, Nakaji-Hirabayashi T, Watanabe T, Hohsaka T, Matsumura K.,ACS Biomater. Sci. Eng.,3,1677-1689,2017
  • Double-Fluorescent-Labeled Single-Chain Antibodies Showing Antigen-Dependent Fluorescence Ratio Change,K. Yoshikoshi, T. Watanabe, T. Hohsaka,Bull. Chem. Soc. Jpn.,89,573-580,2016
  • Atsuko Uyeda, Takayoshi Watanabe, Yasuhiko Kato, Hajime Watanabe, Tetsuya Yomo, Takahiro Hohsaka, Tomoaki Matsuura,Liposome-Based in Vitro Evolution of Aminoacyl-tRNA Synthetase for Enhanced Pyrrolysine Derivative Incorporation,ChemBioChem,16,1797-1802,2015

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◇Lectures and Presentations

  • Incorporation of nonnatural amino acids by expanding the genetic code and its application to fluorescence analysis of proteins,Takahiro Hohsaka,The 14th KIAS Conference on Protein Structure and Function,Korea Institute for Advanced Study, Seoul, Korea,2014.9.18-20
  • Incorporation of nonnatural amino acids through expansion of the genetic code and its application to fluorescence analysis of proteins,Takahiro Hohsaka,The 65th Fujihara Seminar, International Symposium on Synthetic Biology of Unnatural Base Pairs and Amino Acids,Hokkaido,2013.10.3
  • Site-specific incorporation of fluorescent nonnatural amino acids into proteins and its application to fluorescence analysis of proteins,Takahiro Hohsaka,6th International Symposium on Molecular Science of Fluctuations toward Biological Functions,Kyoto,2013.12.5

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■Extramural Activities

◇Academic Society Affiliations

  • The Molecular Biology Society of Japan,2000-
  • The Japanese Biochemical Society,1997-
  • The Chemical Society of Japan,1994-

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■Academic Awards Received

  • The Young Scientists' Prize, The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology,The Minister of Education, Culture, Sports, Science and Technology,20074
  • The First Prize, The 4th Japan Biotechnology Business Competition,The Executive Committee of the Japan Biotechnology Business Competition,2004
  • Gold Medal Award,Tokyo Techno-Forum 21,2003

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