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Kazuaki Matsumura Associate Professor
School of Materials Science、Materials Chemistry Area


Bachelor of Engineering from Kyoto University(1998), Master of Engineering from Kyoto University(2000), Doctor of Engineering from Kyoto University(2004)

■Professional Career

Sub-leader of R & D Team at JST (2003), Research Assistant Professor at Kyoto University (2006)


Biomaterials, Polymer science

■Research Keywords

biomaterials, functional polymer, gel, tissue engineering, cryobiology

■Research Interests

Functional polymeric biomaterials
The creation of functional polymers is a widely studied process for application in biomaterials and tissue engineering materials. Functional polymers have many applications with regard to biomaterials, such as hydrogels, bioabsorbable materials, and artificial bones. In this regard, not only bulky soft materials but also colloids, micelles, and even solutions can be studied as materials for controlling the functions of cells or tissues. Polyampholytes are polymers that have both positive and negative ions in 1 molecule. Our results revealed that several kinds of polyampholytes have a cryoprotective effect on cells in solution. This interesting phenomenon is a characteristic of polymers with high electron charge, especially polyampholytes. From the cryobiological viewpoint, cells are killed because of damage caused by intracellular crystallization of water during freezing. Therefore, we usually add some membrane-permeable chemicals such as dimethyl sulfoxide to cryopreserve cells. However, the phenomenon that non-membrane-penetrating polymers such as polyampholytes can reduce the damage that occurs during freezing cannot be explained on the basis of current knowledge in cryobiology. We will investigate and develop membrane-protective materials that can control cell functions by clarifying the mechanisms underlying such effects. Polyampholytes can change their conformation by controlling the polyion complex and thus exhibit various interesting physicochemical properties. We will try to develop novel functional materials by investigating the interactions between living systems and these polymers and by using the physicochemical properties of the polymers. We also perform basic and applied research on materials well-matched to living systems; this research is aimed toward the regeneration of functions in tissue engineering. In particular, we are trying to develop a novel cell culture scaffold and articular cartilage by using hydrogels with high mechanical properties. The research performed in our laboratory is aimed toward the fusion of chemistry and biology through polymer chemistry and toward the development of materials that can control living systems.



  • Medical Application ofPolyampholytes. In Biopolymers for Medical Applications,Kazuaki Matsumura, Robin Rajan, Sana Ahmed, Minkle Jain,CRC Press,2016,pp 164-181
  • Cell and Materials Interface in Cryobiology and Cryoprotection. In Cell and Material Interface: Advances in Tissue Engineering, Biosensor, Implant, and Imaging Technologies,Kazuaki Matsumura, Minkle Jain, Rajan Robin,CRC Press,2015,pp163-186

◇Published Papers

  • Tuneable dual-thermoresponsive core–shell nanogels exhibiting UCST and LCST behavior.,Rajan R, Matsumura K,Macromol. Rapid. Comm., in press.,2017
  • Magnetic Separation of Autophagosomes from Mammalian Cells using Multifunctional Hybrid Nanobeads.,Takahashi M, Mohan P, Mukai K, Takeda Y, Matsumoto T, Matsumura K, Takakura M, Arai H, Taguchi T, Maenosno S,ACS Omega,2,8,4929-4937,2017
  • StemCell KeepTM is effective for cryopreservation of human embryonic stem cells by vitrification.,Ota A, Matsumura K, Lee JJ, Sumi S, Hyon SH,Cell Transplantation,26,773-787,2017

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◇Lectures and Presentations

  • Biomedical Application of Polyampholytes,Kazuaki Matsumura,SI/SK/SM Workshop 2017,Bangkok,2017/9/26-27
  • 2D Cell Monolayer and 3D Cell Construct Cryopreservation by Slow Vitrification,Kazuaki Matsumura, Keiko Kawamoto, Suong-Hyu Hyon,ESB2015,Poland,8/30-9/3, 2015
  • Tissue-engineered constructs preservation using a novel slow vitrification method with hydrophobically modified polyampholyte to inhibit ice crystallization,Kazuaki Matsumura, Manato Suzuki, Daisuke Tanaka, Suong-Hyu Hyon,10th WBC,Montreal,5/18-22, 2016

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■Extramural Activities

◇Academic Society Affiliations

  • The Chemical Society of Japan,2012-
  • The Society of Polymer Science,2005-
  • Japanese Society for Biomaterials,2005-

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■Academic Awards Received

  • 2014 Young Scientist Award of the Japanese Society for Cryobiology and Cryotechnology,Japanese Society for Cryobiology and Cryotechnology,30
  • The Award for Young Investigator of Japanese Society for Biomaterials (2014),Japanese Society for Biomaterials,201411
  • 2010 Award of Gold Medal in recognition of outstanding contribution towards the advancement of Cryomedicine,Japan society for low temperature medicine,12

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