YAMAGUCHI, Takumi Associate Professor
Materials Science, Bioscience, Biotechnology, and Biomedical Engineering, Research Center for Empathetic and Symbiotic Technology with Nature
◆Degrees
Ph.D from Tokyo University (2008) 東京大学大学院
◆Professional Experience
2015 - : Japan Advanced Institute of Science and Technology , 准教授
2008 - 2015 : Institute for Molecular Science , 助教
◆Specialties
Molecular biochemistry, Biochemistry, Bioorganic chemistry, Structural/physical organic chemistry
◆Research Keywords
分子シミュレーション, 糖鎖, 分子認識, NMR, 超分子化学
◆Research Interests
Elucidation of the structure and biofunction of oligosaccharides
Oligosaccharides play crucial roles in a variety of biological events such as cell-cell communications. For example, many of proteins in the living system are decorated with carbohydrate moieties, which mediate molecular recognition processes. In addition, recent evidence has demonstrated that oligosaccharides on neuronal cell membranes are targets for various proteins that are associated with serious diseases, e.g., Parkinson’s disease, Alzheimer’s disease, and Guillain-Barré syndrome. Our research seeks the underlying molecular basis for the function of oligosaccharides, providing knowledge for the rational design of drugs and biomolecular engineering that contribute towards a detailed understanding of biological systems. 備考_alt

■Publications

◆Published Papers
Biophysical Characterization of p51 and p66 Monomers of HIV-1 Reverse Transcriptase with Their Inhibitors.
Supaphorn Seetaha, Nuntaporn Kamonsutthipaijit, Maho Yagi-Utsumi, Yanaka Seako, Takumi Yamaguchi, Supa Hannongbua, Koichi Kato, Kiattawee Choowongkomon
The protein journal, -, 2023
Symmetry-breaking host–guest assembly in a hydrogen-bonded supramolecular system
Shinnosuke Horiuchi, Takumi Yamaguchi, Jacopo Tessarolo, Hirotaka Tanaka, Eri Sakuda, Yasuhiro Arikawa, Eric Meggers, Guido H. Clever, Keisuke Umakoshi
Nature Communications, 14, 1, -, 2023
Structural Analysis of Oligosaccharides and Glycoconjugates Using NMR
Yoshiki Yamaguchi, Takumi Yamaguchi, Koichi Kato
Advances in Neurobiology, 163-184, 2023
Experimental and computational characterization of dynamic biomolecular interaction systems involving glycolipid glycans
Koichi Kato, Takumi Yamaguchi, Maho Yagi-Utsumi
Glycoconjugate Journal, -, 2022
◆Misc
糖鎖の動的構造解析
加藤晃一, 山口拓実
糖鎖生物学, 109-110, 2020
動的相互作用機構解析に基づいたレクチン高親和性糖鎖の設計
中根健汰, 鈴木達哉, 谷中冴子, 加藤晃一, 山口拓実
日本化学会春季年会講演予稿集(CD-ROM), 99th, -, 2019
IgGのフコシル化によるFcのダイナミクスの変化がFcγ受容体との相互作用に及ぼす影響
谷中冴子, 谷中冴子, 谷中冴子, 谷中冴子, 與語理那, 與語理那, 與語理那, 矢木宏和, 伊藤暁, 伊藤暁, 伊藤暁, 奥村久士, 奥村久士, 奥村久士, 山口拓実, 加藤晃一, 加藤晃一, 加藤晃一, 加藤晃一
日本細胞生物学会大会(Web), 71st, -, 2019
未結合状態の糖鎖のコンフォメーション空間の改変によるレクチン親和性の向上
鈴木達哉, 鈴木達哉, 谷中冴子, 谷中冴子, 渡邉東紀男, YAN Gengwei, 佐藤匡史, 矢木宏和, 山口拓実, 加藤晃一, 加藤晃一
日本糖質学会年会要旨集, 38th, -, 2019
糖鎖コンフォメーション空間の改変による糖-タンパク質間相互作用の制御
山口拓実, 山口拓実, 鈴木達哉, 龍岡博亮, 谷中冴子, 矢木宏和, 佐藤匡史, 加藤晃一, 加藤晃一
ホスト-ゲスト・超分子化学シンポジウム講演要旨集, 17th, -, 2019
◆Books
糖鎖解析技術:核磁気共鳴(NMR)法, 糖質分析
2019
NMR characterization of the conformations, dynamics, and interactions of glycosphingolipids in NMR in Glycoscience and Glycotechnology
161-178, RSC Publishing (Cambridge), 2017
NMR Characterization of the Dynamic Conformations of Oligosaccharides in Modern Magnetic Resonance
Springer, pp 737-754, 2018, 2017
NMR explorations of biomolecular systems with rapid conformational exchanges in Molecular Science of Fluctuations toward Biological Functions
87-103, Springer, 2016
◆Conference Activities & Talks
分子シミュレーションとクラスター分析を用いた高マンノース型糖鎖の動的立体構造解析
第42回 日本糖質学会年会, 2023
Description of the dynamic conformation of oligosaccharides by combining NMR spectroscopy and molecular simulation
第60回 日本生物物理学会年会, 2022
オリゴ糖鎖の立体構造・ダイナミクスの解析と制御
第22回 若手NMR研究会, 2022
Comprehensive characterization of oligosaccharide dynamical conformations by a kernel method in conjunction with graph theoretical techniques
Pacifichem 2021, 2021
常磁性NMR計測を活用した糖鎖の動的立体構造解析法の開発
第38回日本糖質学会年会, 2019

■Teaching Experience

Analysis of Nano-Materials with Training Course, Advanced Biomolecular Science (E), Evaluation of Properties of Materials, Bioscience and Biotechnology(E), ナノ分子解析論(実習付), 先端生体分子科学特論(E), 物性評価特論, 生命機能工学特論(E)

■Contributions to  Society

◆Academic Society Affiliations
THE NUCLEAR MAGNETIC RESONANCE SOCIETY OF JAPAN, THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH, THE CHEMICAL SOCIETY OF JAPAN

■Academic  Awards

・ 日本糖質学会奨励賞 , 山口 拓実 , 2019
・ 自然科学研究機構若手研究者賞 , 山口 拓実 , 2014
・ バイオ関連化学シンポジウム講演賞 , 山口 拓実 , 2013