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Paper by Matsumura lab of Materials Chemistry Area has been selected as a journal front cover.

Paper by Matsumura lab. of Materials Chemistry Area has been selected as a journal front cover.

■Publication
Macromolecular Rapid Communications (Wiley-VCH) 2017. 38, 1700478

■Author
Robin Rajan (Doctoral researcher), Kazuaki Matsumura*

■Title
Tunable Dual-Thermoresponsive Core-Shell Nanogels Exhibiting UCST and LCST Behavior

■Abstract
A core-shell nanogel composed of crosslinked poly-(N-isopropylacrylamide) as the core and poly-sulfobetaine shell is prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization.
These nanogels exhibit tunable dual thermoresponsive behavior, i.e., lower critical solution temperature (LCST) and upper critical solution temperature (USCT). A distinct core and shell were visualized using energy dispersive X-ray spectroscopy, which clearly shows a sulfur-rich shell and a sulfur-deficient core.Transition temperatures can be easily tuned by changing the molecular weight of the constituent polymer.
These nanogels can be efficiently used in temperature-triggered delivery of therapeutic proteins and drugs.

■Reference
http://onlinelibrary.wiley.com/doi/10.1002/marc.201700478/full

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November 22, 2017

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