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Naofumi Shimokawa Senior Lecturer
School of Materials Science、Bioscience and Biotechnology Area

■Degrees

Bachelor from Tokyo Metoropolitan University(2006), Master from Tokyo Metropolitan University(2008), Ph.D. from Kyoto University(2011)

■Professional Career

JSPS Research Fellowship for Young Scientists(DC1)(2008-2011), JSPS Research Fellowship for Young Scientists(PD)(2011-2012),Assistant Professor, Japan Advanced Institute of Science and Technology(2013-2017)

■Specialties

Soft Matter Physics, Biophysics, Physical Chemistry

■Research Keywords

Soft matter, lipid membrane, liposome, phase separation, phase transition, ordered structure

■Research Interests

Ordered-structures induced by electrostatic interaction in lipid bilayer membranes
One of our interest is to reveal the physical properties of lipid bilayer membranes containing charged phospholipids. We reported that the phase separation in charged lipid membranes is suppressed due to electrostatic repulsion between charged head groups experimentally and theoretically. Our goal is to construct the biomimetic system and understand the physico-chemical phenomena in such a system.
Line tension at phase-separated domain boundary
We investigate the specific pattern formation in lipid membranes by controlling the line tension at phase-separated domain boundary.
Dynamical behavior of lipid membrane by coarse-grained molecular dynamics simulation
Our aim is to understand the dyanmical behavior of the lipid membranes using coarse-grained molecular dynamics simulation.

■Publications

◇Published Papers

  • Membrane permeation of giant unilamellar vesicles and corneal epithelial cells with lipophilic vitamin nanoemulsions,Miyuki Miyake, Yasushi Kakizawa, Norio Tobori, Masatoshi Kurioka, Nobuhito Tabuchi, Ryo Kon, Naofumi Shimokawa, Yoshio Tsujino, Masahiro Takagi,Colloids and Surfaces B: Biointerfaces,169,444-452,2018
  • Strikingly different effects of cholesterol and 7-ketocholesterol on lipid bilayer-mediated aggregation of amyloid beta (1-42),Huong T. T. Phan, Naofumi Shimokawa, Neha Sharma, Masahiro Takagi, Mun'delanji C. Vestergaad,Biochemistry and Biophysics Reports,14,98-103,2018
  • Size-dependent uptake of electrically neutral amphipathic polymeric nanoparticles by cell-sized liposomes and an insight into their internalization mechanism in living cells,Shoko Ichikawa, Naofumi Shimokawa, Masahiro Takagi, Yukiya Kitayama, Toshifumi Takeuchi,Chemical Communications,54,4557-4560,2018

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◇Lectures and Presentations

  • Physical properties of the hybrid lipid POPC on micrometer-sized domains in mixed lipid membranes,Naofumi Shimokawa,1st International Symposium on Bioscience and Biotechnology in JAIST,石川ハイテク交流センター,2016,03,18

■Extramural Activities

◇Academic Society Affiliations

  • Division of Colloid and Surface Chemistry,2009-
  • The Physical Society of Japan,2005-