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Takumi Yamaguchi Associate Professor
School of Materials Science、Bioscience and Biotechnology Area


B.S. from Tokyo University (2003), M.S. from Tokyo University (2005), Ph.D from Tokyo University (2008)

■Professional Career

JSPS Research Fellow at Tokyo University(DC1)(2005), Technical Assistant of School of Engineering at Tokyo University(2008), Assistant Professor of Institute for Molecular Science at National Institutes of Natural Sciences(2008), Associate Professor of School of Materials Science, Japan Advanced Institute of Science and Technology (2015)


Carbohydrate research, Organic chemistry, Biofunctional chemistry, Supramolecular chemistry

■Research Keywords

Oligosaccharides, Molecular recognition

■Research Interests

Elucidation of the structure and biofunction of oligosaccharides
Oligosaccharides play crucial roles in a variety of biological events such as cell-cell communications. For example, many of proteins in the living system are decorated with carbohydrate moieties, which mediate molecular recognition processes. In addition, recent evidence has demonstrated that oligosaccharides on neuronal cell membranes are targets for various proteins that are associated with serious diseases, e.g., Parkinson’s disease, Alzheimer’s disease, and Guillain-Barré syndrome. Our research seeks the underlying molecular basis for the function of oligosaccharides, providing knowledge for the rational design of drugs and biomolecular engineering that contribute towards a detailed understanding of biological systems.



  • "NMR explorations of biomolecular systems with rapid conformational exchanges" in Molecular Science of Fluctuations toward Biological Functions,M. Yagi-Utsumi, T. Yamaguchi, R. Kitahara, K. Kato,Springer,2016,87-103
  • "NMR characterization of the conformations, dynamics, and interactions of glycosphingolipids" in NMR in Glycoscience and Glycotechnology,M. Yagi-Utsumi, T. Yamaguchi, Y. Uekusa, K. Kato,RSC Publishing (Cambridge),2017,161-178
  • "NMR Characterization of the Dynamic Conformations of Oligosaccharides" in Modern Magnetic Resonance,K. Kato, H. Yagi, T. Yamaguchi,Springer,2017

◇Published Papers

  • Conformational dynamics of oligosaccharides characterized by paramagnetism-assisted NMR spectroscopy in conjunction with molecular dynamics simulation,Y. Zhang, T. Yamaguchi, T. Satoh, M. Yagi-Utsumi, Y. Kamiya, Y. Sakae, Y. Okamoto, K. Kato,Adv. Exp. Med. Biol.,842,217,2015
  • A self-assembled, π-stacked complex as a finely-tunable magnetic aligner for biomolecular NMR applications,S. Sato, R. Takeuchi, M. Yagi-Utsumi, T. Yamaguchi, Y. Yamaguchi, K. Kato, M. Fujita,Chem. Commun.,51,2540,2015
  • NMR-based structural validation of therapeutic antibody produced in Nicotiana benthamiana,H. Yagi, N. Fukuzawa, Y. Tasaka, K. Matsuo, Y. Zhang, T. Yamaguchi, S. Kondo, S. Nakazawa, N. Hashii, N. Kawasaki, T. Matsumura, K. Kato,Plant Cell Rep.,34,959,2015

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◇Lectures and Presentations

  • Paramagnetic Lanthanide-tagging for NMR Characterization of The Conformational Dynamics of Oligosaccharides,Takumi Yamaguchi and Koichi Kato,IMS Asian International Symposium "Supramolecular Dynamics at the Interface of Chemistry and Biology",岡崎統合バイオサイエンスセンター(岡崎),2015年6月12日
  • Design and creation of Lewis X-expressing glycoclusters toward functional analyses of oligosaccharides in membrane systems,T. Yamaguchi, G. Yan, H. Yagi, K. Kato,8th Japan-Korea Seminars on Biomolecular Science: Experiments and Simulation,岡崎コンファレンスセンター(岡崎),2016年2月16日
  • Chemical synthesis and modification of oligosaccharides toward controlling their biofunctions,T. Yamaguchi,DU-JAIST Indo-Japan Symposium on Chemistry of Functional Molecules/ Materials,University of Delhi (New Delhi, India),2016年2月26日

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